PittsburghV1, Main, Exploration, bibRecord, 003531

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).

Identifieur interne : 003531 ( Main/Exploration ); précédent : 003530; suivant : 003532

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).

Auteurs : Michael Nguyen [États-Unis] ; Andrew Roth [États-Unis] ; Evan J. Kyzar [États-Unis] ; Manoj K. Poudel [États-Unis] ; Keith Wong [États-Unis] ; Adam Michael Stewart [États-Unis] ; Allan V. Kalueff [États-Unis]

Source :

Neurochemistry international [ 1872-9754 ] ; 2014.

RBID : pubmed:24412511

Descripteurs français

English descriptors

KwdEn :
- Animals, Brain (physiology), Child Development Disorders, Pervasive (diagnosis), Child Development Disorders, Pervasive (genetics), Child Development Disorders, Pervasive (metabolism), Dopamine (genetics), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (genetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Dopaminergic Neurons (physiology), Humans, Neural Pathways (physiology), Receptors, Dopamine (genetics), Receptors, Dopamine (metabolism), Signal Transduction (physiology).
MESH :
- chemical , genetics : Dopamine, Dopamine Plasma Membrane Transport Proteins, Receptors, Dopamine.
- diagnosis : Child Development Disorders, Pervasive.
- genetics : Child Development Disorders, Pervasive.
- metabolism : Child Development Disorders, Pervasive, Dopamine, Dopamine Plasma Membrane Transport Proteins, Receptors, Dopamine.
- physiology : Brain, Dopaminergic Neurons, Neural Pathways, Signal Transduction.
- Animals, Humans.

Abstract

Autism spectrum disorder (ASD) is a debilitating brain illness causing social deficits, delayed development and repetitive behaviors. ASD is a heritable neurodevelopmental disorder with poorly understood and complex etiology. The central dopaminergic system is strongly implicated in ASD pathogenesis. Genes encoding various elements of this system (including dopamine receptors, the dopamine transporter or enzymes of synthesis and catabolism) have been linked to ASD. Here, we comprehensively evaluate known molecular interactors of dopaminergic genes, and identify their potential molecular partners within up/down-steam signaling pathways associated with dopamine. These in silico analyses allowed us to construct a map of molecular pathways, regulated by dopamine and involved in ASD. Clustering these pathways reveals groups of genes associated with dopamine metabolism, encoding proteins that control dopamine neurotransmission, cytoskeletal processes, synaptic release, Ca(2+) signaling, as well as the adenosine, glutamatergic and gamma-aminobutyric systems. Overall, our analyses emphasize the important role of the dopaminergic system in ASD, and implicate several cellular signaling processes in its pathogenesis.

DOI: 10.1016/j.neuint.2014.01.002
PubMed: 24412511

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Autism spectrum disorder (ASD) is a debilitating brain illness causing social deficits, delayed development and repetitive behaviors. ASD is a heritable neurodevelopmental disorder with poorly understood and complex etiology. The central dopaminergic system is strongly implicated in ASD pathogenesis. Genes encoding various elements of this system (including dopamine receptors, the dopamine transporter or enzymes of synthesis and catabolism) have been linked to ASD. Here, we comprehensively evaluate known molecular interactors of dopaminergic genes, and identify their potential molecular partners within up/down-steam signaling pathways associated with dopamine. These in silico analyses allowed us to construct a map of molecular pathways, regulated by dopamine and involved in ASD. Clustering these pathways reveals groups of genes associated with dopamine metabolism, encoding proteins that control dopamine neurotransmission, cytoskeletal processes, synaptic release, Ca(2+) signaling, as well as the adenosine, glutamatergic and gamma-aminobutyric systems. Overall, our analyses emphasize the important role of the dopaminergic system in ASD, and implicate several cellular signaling processes in its pathogenesis.</div>
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Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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